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Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

Identifieur interne : 002397 ( Main/Exploration ); précédent : 002396; suivant : 002398

Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

Auteurs : Martin Walker [Royaume-Uni] ; Sabine Specht [Allemagne] ; Thomas S. Churcher [Royaume-Uni] ; Achim Hoerauf [Allemagne] ; Mark J. Taylor [Royaume-Uni] ; María-Gloria Basá Ez [Royaume-Uni]

Source :

RBID : PMC:4370165

Abstract

The efficacy of 4–6 weeks of oral doxycycline in depleting Wolbachia from Onchocerca volvulus is >95% in the majority of patients. Wolbachia depletion induces a 70%–80% reduction in worm life span, confirming doxycycline as a potent macrofilaricide.


Url:
DOI: 10.1093/cid/ciu1152
PubMed: 25537873
PubMed Central: 4370165


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<p>The efficacy of 4–6 weeks of oral doxycycline in depleting
<italic>Wolbachia</italic>
from
<italic>Onchocerca volvulus</italic>
is >95% in the majority of patients.
<italic>Wolbachia</italic>
depletion induces a 70%–80% reduction in worm life span, confirming doxycycline as a potent macrofilaricide.</p>
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<name sortKey="Gyapong, Jo" uniqKey="Gyapong J">JO Gyapong</name>
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<name sortKey="Walker, Martin" sort="Walker, Martin" uniqKey="Walker M" first="Martin" last="Walker">Martin Walker</name>
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